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Lactobacillus fermentum is another of the Lactobacillus species belonging to the phylum of Firmicutes. It is found in the human intestinal tract and urogenital tract. It is common in fermenting animal and plant material and resistant to certain antibiotics, which seems to be a natural or intrinsic characteristic of this type of bacteria (1).

It has been used for the treatment of different conditions such as urogenital infections in women and reducing cholesterol levels. Specifically human clinical studies performed on strain Lactobacillus fermentum ME-3 which have shown a reduction of oxidized LDL cholesterol, which is a major contributor to atherosclerosis development (2,3). Mice treated with a combination of ofloxacin and ME-3 revealed a reduction in liver and spleen granulomas of Salmonella thphimurium (2).



  1. Ishiwa, Hiromi, and Shin Iwata. “Drug Resistance Plasmids in Lactobacillus Fermentum.” Journal of General and Applied Microbiology 26, no. 1 (1979): 71-74.
  2. Mikelsaar, Marika, and Mihkel Zilmer. “Lactobacillus fermentum ME-3 An antimicrobial and antioxidative probiotic.” Microbial Ecology in Health and Disease 21, no. 1 (2009): 1-27.
  3. Pan, Dao D., Xia Q. Zeng, and Tian Yan. “Characterization of Lactobacillus fermentum SM-7 isolated from koumiss, a potential probiotic bacterium with cholesterol-lowering effects.” Journal of the Science of Food and Agriculture 91, no. 3 (2011): 512-518.
  4. John-Hwan, Park, Yeonhee Lee, Enpyo Moon, Seun-Hyeok Seok, and Min-Won Baek. “Safety Assessment of lactobacillus fermentum PL 9005, a Potential Probiotic Lactic Acid Bacterium, in Mice.” Journal of Microbiology and Biotechnology 15, no. 3 (2005): 603-608.
  5. Zeng, Xian Q., Dao D. Pan, and Pei D. Zhou. “Functional Characteristics of Lactobacillus fermentum F1.” Current Microbiology 62, no. 1 (2010): 27-31