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Lactobacillus casei is found in the human intestine and mouth. It is part of the phylum of Firmicutes and the genus Lactobacillus. It is used for the production of dairy products especially for ripening cheddar cheese (1). Hence its name is derived from the Latin root caseus for cheese. It is used in the natural fermentation of beans to lower levels of the compounds causing gas upon digestion (2).

A number of studies have been done to determine its therapeutic effects. Along with other probiotics ,it has been shown to be helpful  in the treatment of  antibiotic-associated diarrhea (AAD) and Clostridium difficile infections (CDI) (3). It has been shown to provide a significantly shorter recovery times in children suffering from acute diarrhea (primarily caused by rotavirus) as compared to placebo(4,5). Administration of lactobacillus casei prior to an inflammatory insult to the bowel prevents the development of increased intestinal permeability (6,7). Research has been done on the L. casei strain Shirota  to determine it effects of NK-cell activity and Helicobacter pylori (8.9).




  1. Banks JM, Williams AG; Williams (2004). “The role of the nonstarter lactic acid bacteria in Cheddar cheese ripening”. International Journal of Dairy Technology. 57 (2–3): 145–152. doi:10.1111/j.1471-0307.2004.00150.x. Retrieved 2013-10-30.
  2. Marisela Granito, Glenda Álvarez; Álvarez (June 2006). “Lactic acid fermentation of black beans (Phaseolus vulgaris): microbiological and chemical characterization”. Journal of the Science of Food and Agriculture. 86 (8): 1164–1171. doi:10.1002/jsfa.2490.
  3. McFarland, LV (2009). “Evidence-based review of probiotics for antibiotic-associated diarrhea and Clostridium difficile infections” (PDF). Anaerobe. 15 (6): 274–80. doi:10.1016/j.anaerobe.2009.09.002. PMID 19825425. Retrieved 2012-04-15.
  4. Isolauri, Erika;; et al. (1991). “A Human Lactobacillus Strain (Lactobacillus casei sp strain GG) Promotes Recovery From Acute Diarrhea in Children”. Pediatrics. 88 (1): 90–97. PMID 1905394. Retrieved 2012-04-15.
  5. Van Niel, C. W.; Feudtner, C.; Garrison, M. M.; Christakis, D. A. (2002). Lactobacillus Therapy for Acute Infectious Diarrhea in Children: A Meta-analysis”. Pediatrics. 109 (4): 678–684. doi:10.1542/peds.109.4.678. PMID 11927715.
  6. Eun, CS.; Kim, YS.; Han, DS.; Choi, JH.; Lee, AR.; Park, YK. (Jan 2011). “Lactobacillus casei prevents impaired barrier function in intestinal epithelial cells”. APMIS. 119 (1): 49–56. doi:10.1111/j.1600-0463.2010.02691.x. PMID 21143526.
  7. Zakostelska, Z.; Kverka, M.; Klimesova, K.; Rossmann, P.; Mrazek, J.; Kopecny, J.; Hornova, M.; Srutkova, D.; et al. (2011). “Lysate of probiotic Lactobacillus casei DN-114 001 ameliorates colitis by strengthening the gut barrier function and changing the gut microenvironment”. PLOS ONE. 6 (11): e27961. doi:10.1371/journal.pone.0027961. PMC 3222668Freely accessible. PMID 22132181.
  8. Kazuyoshi Takeda; Ko Okumura. “Effects of a Fermented Milk Drink Containing Lactobacillus casei Strain Shirota on the Human NK-Cell Activity”.
  9. Cats A, Kuipers EJ, Bosschaert MA, Pot RG, Vandenbroucke-Grauls CM, Kusters JG; Kuipers; Bosschaert; Pot; Vandenbroucke-Grauls; Kusters (February 2003). “Effect of frequent consumption of a Lactobacillus casei-containing milk drink in Helicobacter pylori-colonized subjects”. Aliment. Pharmacol. Ther. 17 (3): 429–35. doi:10.1046/j.1365-2036.2003.01452.x. PMID 12562457.